A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
نویسندگان
چکیده
منابع مشابه
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
CBF1 is a member of the CSL family of DNA binding factors, which mediate either transcriptional repression or transcriptional activation. CSL proteins play a central role in Notch signaling and in Epstein-Barr virus-induced immortalization. Notch is a transmembrane protein involved in cell-fate decisions, and the cytoplasmic domain of Notch (NotchIC) targets CBF1. The Epstein-Barr virus-immorta...
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The Notch signaling pathway is highly conserved across different animal species and plays crucial roles in development and physiology. Regulation of Notch signaling occurs at multiple levels in different tissues and cell types. Here, we show that the histone deacetylase HDAC1 acts as a positive regulator of Notch signaling during Drosophila wing development. Depletion of HDAC1 causes wing notch...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1998
ISSN: 0890-9369
DOI: 10.1101/gad.12.15.2269